Vanni Cuoghi has participated in numerous biennials in Italy and abroad, including the Saint Petersburg Biennale (2008), the Prague Biennale (2009), the 54th Venice Biennale at the Corderie dell’Arsenale, Padiglione Italia (2011), the 56th Venice Biennale, Collateral Italia Docet (2015), and the Italy-China Biennale (2012). He has also exhibited in public institutions such as Palazzo Reale in Milan (2007), Haidian Exhibition Center in Beijing during the XXXIX Olympic Games (2008), Liu Haisu Museum in Shanghai (2008), the Museum of Contemporary Art in Perm, Russia (2010), Castello Sforzesco in Milan (2012), Fabbrica del Vapore in Milan (2015), and Vestfossen Kunstlaboratorium Museum in Norway (2018).
His works have been showcased at several Italian and international art fairs, including Frieze (London), MiArt (Milan), Artefiera (Bologna), Scope (New York), Off (Brussels), Daegu Art Fair (South Korea), and KIAF in Seoul (South Korea).
In 2012, commissioned by Costa Crociere, he created eight large paintings for the Costa Fascinosa cruise ship, followed by six paintings for Costa Diadema in 2014.
Since October 2015, he has been the Chair of Painting at the Aldo Galli Academy in Como.

Among his major solo exhibitions are Novus Malleus Maleficarum (2011) at San Pietro in Atrio and Palazzo Volpi Art Gallery in Como; Aion (2013) at the Civic Museums of Crema; Da Cielo a Terra (2016) at the Jewish Museum of Bologna; The Invisible Sun (2017) at the Francesco Messina Museum in Milan.
In May 2019, he inaugurated The Eye of the Storm, a solo exhibition at Rossi-Martino Gallery in Hong Kong, followed by Esuli Pensieri at Fondazione Balestra in Longiano (FC) in October.
In July 2020, he presented Apnea, curated by Elisabetta Sgarbi at the Argenterie in Villa Reale, Monza.

In 2021, he inaugurated Submariner at the Civic Aquarium of Milan, curated by Nicoletta Castellaneta and Ivan Quaroni. In 2022, he participated in Eccentrici, Apocalittici, Pop. Inferno e delizia nell’arte contemporanea at the Civic Gallery of Trento, Acque Chiare, Acque Scure at the Civic Museum of Noto (SR), curated by Aldo Premoli, and the Connexxion Festival in Savona, organized by Espoarte magazine and curated by Livia Savorelli.
In 2023, he took part in the group exhibition Fiat Lux, curated by Aldo Premoli at the Diocesan Museum of Noto (SR), and presented Plinio. Effetto Serra, a solo show at Villa Bernasconi in Cernobbio (CO), celebrating the 2000th anniversary of the birth of the Latin writer.
In 2024, he was invited by Demetrio Paparoni to the Interaction Biennale at Fondazione Made in Cloister in Naples and, in May, will participate in the Rimini Biennale of Drawing, curated by Massimo Pulini and Andrea Lo Savio, at the City Museum.